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Chris Garcia''s Profile | Stanford Profiles

Chris Garcia is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.

A reasoned approach to the treatment of autoimmune ...

2021-6-23 · Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease affecting all ages, characterised by elevated transaminase and immunoglobulin G levels, positive autoantibodies, interface hepatitis on histology and good response to immunosuppressive treatment. If untreated, it has a poor prognosis. The aim of this review is to analyse AIH ...

IJMS | Free Full-Text | Tumor Infiltrating Regulatory T ...

Regulatory T cells represent a class of specialized T lymphocytes that suppress unwanted immune responses and size the activation of the immune system whereby limiting collateral damages in tissues involved by inflammation. In cancer, the accumulation of Tregs is generally associated with poor prognosis. Many lines of evidence indicate that Tregs accumulation in the tumor microenvironment …

(PDF) The Role of Alternative Splicing in the Control of ...

2015-12-22 · Alternative splicing of the Ptprc gene. The Ptprc gene can give rise to multiple isoforms through alternative splicing of pre-mRNA that involves three variable exons 4, 5 and 6.

(PDF) Lymphocyte expansion in bioreactors: upgrading ...

ability to specifically distinguish, bind and kill abnor-mally growing cells by selectively switching metabolic. pathways to enhance the production of cytotoxic sub-stances [20]. Because of this ...

Amazon : Books

Amazon Books has the world''s largest selection of new and used titles to suit any reader''s tastes. Find best-selling books, new releases, and classics in every category, from Harper Lee''s To Kill a Mockingbird to the latest by Stephen King or the next installment in the Diary of a Wimpy Kid children''s book series. Whatever you are looking for: popular fiction, cookbooks, mystery ...

Reprogramming of CTLs into natural killer–like cells in …

2007-5-12 · Reprogramming of CTLs into natural killer–like cells in celiac disease20062035,Department of Pathology,Department of Pediatrics,Department of Medicine, andDepartment of Health Studies, University of Chicago ...

Museum – Art in America Guide

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2020-11-16 · CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope[J]. J Clin Investig, 2008, 118(10): 3390-3402. DOI:10.1172/JCI35449

Mechanisms of Tumor Cell–Intrinsic Immune Evasion | …

2019-10-27 · The immune system has the potential to recognize and eliminate tumor cells, and failed immune surveillance contributes to cancer development. Many immunotherapeutics, including checkpoint blockade therapy, harness the endogenous antitumor immune response. While clinical benefit can be profound in some cases, some patients show primary resistance, whereas others experience clinical …

Cellular based immunotherapy for primary liver cancer ...

2021-8-9 · Primary liver cancer (PLC) is a common malignancy with high morbidity and mortality. Poor prognosis and easy recurrence on PLC patients calls for optimizations of the current conventional treatments and the exploration of novel therapeutic strategies. For most malignancies, including PLC, immune cells play crucial roles in regulating tumor microenvironments and specifically recognizing …

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Engineering immunomodulatory biomaterials for type 1 ...

A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary therapies that seek to ...

Cancers | Free Full-Text | Immune Checkpoint Ligand ...

The so-called immune checkpoints are pathways that regulate the timing and intensity of the immune response to avoid an excessive reaction and to protect the host from autoimmunity. Immune checkpoint inhibitors (ICIs) are designed to target the negative …

Theranostic cells: emerging clinical applications of ...

2021-7-7 · Theranostic cells are engineered to express sensors that detect the presence of a disease marker (for example, a cell surface receptor that targets a ligand) and signalling machinery that ...

Pathogenesis of Type 1 Diabetes | SpringerLink

2018-3-19 · Abstract. Type 1 diabetes (T1D) is considered a multifactorial, chronic, autoimmune disease in which autoreactive T-lymphocytes cause severe loss of pancreatic beta cells. Much progress has been done in the discovery of disease-predisposing genes, the identification of islet cell autoantigens, and key features of islet autoimmune responses.

Clinical translation and challenges in cancer ...

3. Drug development considerations for clinical translation. Clinical translation of cancer immunotherapy involves the development of small molecules (adjuvants) and biologics, each bringing a different set of challenges with it and therefore altered the course of development.

Lymphocyte expansion in bioreactors: upgrading adoptive ...

2021-4-13 · Bioreactors are essential tools for the development of efficient and high-quality cell therapy products. However, their application is far from full potential, holding several challenges when reconciling the complex biology of the cells to be expanded with the need for a manufacturing process that is able to control cell growth and functionality towards therapy affordability and opportunity.

IJMS | Free Full-Text | Latest Advances in Targeting the ...

2019-9-23 · The tumor bulk is composed of a highly heterogeneous population of cancer cells, as well as a large variety of resident and infiltrating host cells, extracellular matrix proteins, and secreted proteins, collectively known as the tumor microenvironment …

Overview of Infections in the Immunocompromised Host

2021-9-11 · B. Overview of Host Defenses. Host defense depends upon physical barriers, as well as the immune system. In conceptual terms, the components of the immune system can be divided into two compartments – innate and adaptive – with fundamentally different modes of action (Table 1) nate host defense mechanisms are rapid (minutes to hours), depend upon patterned responses to pathogens …

The intersection of radiotherapy and immunotherapy ...

The role of NF-κB in radiation-induced inflammation. The NF-κB pathway is a master regulator of both innate and adaptive immunity. NF-κB is a transcription factor composed of homo- or heterodimers of the NF-κB/Rel family: RelA (p65), RelB, c-Rel, p50/p105 (NF-κB1) and p52/p100 (NF-κB2).

Nucleic Acid Sensors as Therapeutic Targets for Human ...

McWhirter and Jefferies review the mechanisms that link nucleic acid sensors, including TLR, RLR, and cGAS/STING, to infectious disease, cancer, and autoimmune and inflammatory disorders. The authors describe agonists and antagonists targeting nucleic acid sensors and emerging therapeutic strategies currently under investigation.

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Unconventional T Cell Targets for Cancer Immunotherapy ...

Unconventional T Cell Targets for Cancer Immunotherapy. Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility complex (MHC) class I and MHC class II molecules, respectively. However, unconventional T cells, which ...

CD3e Monoclonal Antibody (145-2C11), eBioscience ...

Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell. 2014;157:1309-23 pubmed publisher Wang G, Wu K, Li W, Zhao E, Shi L, Wang J, et al .

CD3 bispecific antibody–induced cytokine release is ...

The ability of T cells to secrete cytokines is commonly used as a marker for T cell activity and to reflect the potential to kill target cells; however, human peripheral T cells induced a robust dose-dependent killing of target cells on the second dose . Therefore, T cells with prior TDB exposure retained killing potency despite the lack of ...